Journal of Biometrics & Biostatistics

Feng Gao

Publications

• Research Article
  Diagnostic Utility of Gene Expression Profiles
  Author(s): Chengjie Xiong, Yan Yan and Feng GaoChengjie Xiong, Yan Yan and Feng Gao
  
  Two crucial problems arise from a microarray experiment in which the primary objective is to locate differentially expressed genes for the diagnosis of diseases such as cancer and Alzheimer’s. The first problem is the detection of a subset of genes which provides an optimum discriminatory power between diseased and normal subjects, and the second problem is the statistical estimation of discriminatory power from the optimum subset of genes between two groups of subjects. We develop a new method to select an optimum subset of discriminatory genes by searching over possible linear combinations of gene expression profiles and locating the one which provides the maximum discriminatory power between two sources of RNA as measured by the area under the receiver operating characteristic (ROC) curve. We further provide an estimate to the optimum discriminatory power between th.. Read More»
  DOI: 10.4172/2155-6180.1000158

  Abstract PDF