Journal of Computer Science & Systems Biology

Fiedler AJ

Publications

• Research Article
  Homeomorphic Matlab Model of Myopia Development
  Author(s): Hung GK, Fiedler AJ and Ciuffreda KJHung GK, Fiedler AJ and Ciuffreda KJ
  
  A homeomorphic biomechanical model of the eye based on the Incremental Retinal-Defocus Theory (IRDT) was developed to simulate myopic and hyperopic growth under different optical defocus conditions. The IRDT states that the time-integrated reduction in retinal-image defocus magnitude decreases the rate of retinal neuromodulator release, which in turn decreases the rate of proteoglycan synthesis and reduces scleral structural integrity, thus resulting in axial elongation and myopia development. A homeomorphic biomechanical model of the eye was constructed to test the IRDT based only on optical defocus and its resultant contribution to mechanical forces acting on the components of the eye. The Matlab simulation results showed a more fl attened oblate shape for myopic defocus, and a more elongated prolate shape with hyperopic defocus. Thus, the homeomorphic b.. Read More»
  DOI: 10.4172/jcsb.1000052

  Abstract PDF