Cancer Science & Therapy

Francesco Barillaro

Publications

• Research Article
  Characterization of Kallireins and microRNAs in Urine Sediment for the Discrimination of Prostate Cancer from Benign Prostatic Hyperplasia
  Author(s): Maria G. Egidi, Gabriella Guelfi, Giovanni Cochetti, Giulia Poli, Francesco Barillaro, Danilo Zampini, Luca Mechelli and Ettore MeariniMaria G. Egidi, Gabriella Guelfi, Giovanni Cochetti, Giulia Poli, Francesco Barillaro, Danilo Zampini, Luca Mechelli and Ettore Mearini
  
  Objectives: Prostate Cancer (PCa) and Benign Prostatic Hyperplasia (BPH) are frequently coexisting in elderly men. The measurement of serum PSA together with Digital Rectal Examination (DRE) represents the primary diagnostic tool to suspect PCa, whereas definitive diagnosis is achieved by prostate biopsy. The low specificity of PSA and the modest detection rate of biopsy convict the patient to a quite often unnecessary and uncomfortable clinical itinerary. There is a urgent need for new and more accurate methodologies to diagnosize PCa. In the present study, the expression of 4 mRNAs and 2 miRNAs was evaluated in post DRE urine cell pellets from patients suffering PCa and age-matched subjects affected by BPH with elevated PSA levels. We also evaluated the diagnostic accuracy of markers in predicting PCa. .. Read More»
  DOI: 10.4172/1948-5956.1000337

  Abstract PDF