Benin
Research Article
Impact of Simultaneous Exposure to Lead and Efavirenz on Some Biochemical Markers in Wistar Rats
Author(s): Alain K. Aïssi, Lauris Fah, Casimir D. Akpovi, Jean Robert Klotoé, Victorien T. Dougnon, Patient Guédénon, Patrick A. Edorh and Frédéric LokoAlain K. Aïssi, Lauris Fah, Casimir D. Akpovi, Jean Robert Klotoé, Victorien T. Dougnon, Patient Guédénon, Patrick A. Edorh and Frédéric Loko
Chronic exposure to heavy metals including lead remains a serious problem for humanity. The current study aims to evaluate the impact of co-exposure to lead (Pb) and Efavirenz (EFV) on some biochemical parameters in blood. Twenty eight Wistar rats were divided equally into four groups respectively orally fed with lead acetate at 10 mg/kg (GPb), EFV at 20 mg/kg (GEfv), both xenobiotics (GPb+Efv), and distilled water (GCtrl). On Day 0 and Day 28, the blood of each animal was collected and biochemical assays were conducted. Data were processed with SPSS 16.0. The results showed a significant decrease in total proteinemia, albuminemia, serum calcium and iron as well as a significant increase in blood urea and uric acid in group exposed to lead. The aforementioned changes were more pronounced in group GPb+Efv. Besides, significant increases in total cholesterolemia were observed in GEfv an.. Read More»
DOI:
10.4172/2161-0525.1000220
Environmental & Analytical Toxicology received 6818 citations as per Google Scholar report