Journal of Cytology & Histology

Gabriela Souto Vieira-de-Mello

Publications

• Research Article
  Lectin Histochemistry Reveals Changes in Carbohydrate Expression on Morphological Types of Breast Ductal Carcinoma in situ
  Author(s): Gabriela Souto Vieira-de-Mello, Antônio Felix da Silva Filho, Petra Barros dos Santos, Moacyr Jesus Barreto de Melo Rêgo and Eduardo Isidoro Carneiro BeltrãoGabriela Souto Vieira-de-Mello, Antônio Felix da Silva Filho, Petra Barros dos Santos, Moacyr Jesus Barreto de Melo Rêgo and Eduardo Isidoro Carneiro Beltrão
  
  Breast Ductal Carcinoma in situ (DCIS) show a high degree of architectural heterogeneity and what kind of DCIS lesions will progress to invasive disease remains unknown. Thus, its characterization remains a complex process. In addition, in the same tumor we can find different types of lesions that presented different biological behaviour and morphology. Carbohydrate expression changes play crucial roles in carcinogenesis of the breast, becoming the study these changes a useful tool for an accurate predictor. In this context, this work aimed analyzed the differential expression of specific carbohydrates among the DCIS lesion through lectin histochemistry and its correlation with its behaviors. Glycobiology expression of 218 DCIS samples of human breast cancer was investigated by MAL-II, PNA, WGA, PHA-L and SNA lectins. MAL-II was more ex.. Read More»
  DOI: 10.4172/2157-7099.1000179

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