Journal of Clinical Case Reports

Gaetano La Manna

Publications

• Case Report
  Rituximab as First-Line Therapy in Severe Lupus Erythematosus with Neuropsychiatric and Renal Involvement: A Case-Report and Review of the Literature
  Author(s): Andrea Angeletti, Olga Baraldi, Anna Laura Chiocchini, Giorgia Comai, Paolo Cravedi and Gaetano La MannaAndrea Angeletti, Olga Baraldi, Anna Laura Chiocchini, Giorgia Comai, Paolo Cravedi and Gaetano La Manna
  
  Neuropsychiatric and renal involvement are common in systemic lupus erythematosus with negative impact on patient survival. Glucocorticoids, antiproliferative and cytotoxic agents represent first-line therapies, but are often ineffective and are burdened by significant toxicities. Despite the negative results of two randomized controlled trials, rituximab is still widely used as second- or third-line therapy in similar cases. No case has been reported so far where rituximab has been used as first-line therapy. We report the case of a 60-year-old cCaucasian woman with concurrent neuropsychiatric and renal lupus erythematous treated with one cycle of rituximab therapy at disease onset. Treatment was well tolerated and at 24 months the patient is in complete remission and free of immunosuppression. To the best of our knowledge, this is the first case of neuropsychiatric and ren.. Read More»
  DOI: 10.4172/2165-7920.10001033

  Abstract PDF