Journal of Computer Science & Systems Biology

Galla Venkatasatyanarayana

Publications

• Research Article
  Screening and Docking Studies of 266 Compounds from 7 Plant Sources as Antihypertensive Agents
  Author(s): Enireddy Vamsidhar, Galla Venkata Swamy, Sashikanth Chitti, P Ajay Babu, Galla Venkatasatyanarayana and Adidela Daveedu RajuEnireddy Vamsidhar, Galla Venkata Swamy, Sashikanth Chitti, P Ajay Babu, Galla Venkatasatyanarayana and Adidela Daveedu Raju
  
  Various proteins play important roles in hypertension and a number of plants have been tested for their efficacy in modulating hypertension. Angiotensin 1-converting enzyme, renin and extracellular regulated kinase 2(ERK2) proteins, respectively, has major role in hypertension and therefore protein - ligand interaction studies were performed on 266 compounds from different parts of 7 plants (Allium sativum, Coriandrum sativum, Dacus carota, Murrayya koneigii, Eucalyptus globus, Calendula officinalis and Lycopersicon esculentum). Analysis was conducted using GOLD (Genetic Optimisation for Ligand Docking) software as docking program and the molecules drawn in ISIS Draw software are energy minimized using cosmic - optimize 3D module of Tsar (Tools for structure activity relationships) software. Before docking plant compounds, software validation was performed.. Read More»
  DOI: 10.4172/jcsb.1000050

  Abstract PDF