Journal of Environmental Analytical Chemistry

George Perry

Publications

• Research Article
  Ferric Iron Brain Deposition as the Cause, Source and Originator of Chronic Neurodegenerative Diseases
  Author(s): Lucijan Mohorovic, Anna Lavezzi, Sanja Stifter, George Perry, Djulija Malatestinic, Vladimir Micovic and Eris MaterljanLucijan Mohorovic, Anna Lavezzi, Sanja Stifter, George Perry, Djulija Malatestinic, Vladimir Micovic and Eris Materljan
  
  We want to understand the sources of oxidants as factors in understanding the role they play in the pathogenesis of neurodegeneration, such as Alzheimer’s disease (AD). Our earlier observations pointed to the difference of intracellular iron when it originates from physiological hemoglobin versus pathological methemoglobin degradation, where heme oxygenation of hemoglobin results in ferrous (Fe2+) iron, while methemoglobin catabolism produces ferric (Fe3+) iron. Methemoglobin plays the role of carrier, donor and source of cytotoxic redox-active ferric (Fe3+) iron and also plays a critical role as an originator of neurodegenerative diseases. Environmental toxicity factors determine a permanent intracellular source of redox-active ferric (Fe3+) iron which without ferrous-ferric inversions, ‘in situ’, has a direct impact on the endothelial small vessels of the brain, in.. Read More»
  DOI: 10.4172/2380-2391.1000169

  Abstract PDF