Internal Medicine, Hospital of the Johann Wolfgang Goethe University,
Theodor Stern Kai 7 , D-60590 Frankfurt/Main
Germany
Research Article
Prognostic Value of Bone Marker Beta-Crosslaps in Patients with Breast Carcinoma
Author(s): Nicole Zulauf, Ingo Marzi and Gerhard M OremekNicole Zulauf, Ingo Marzi and Gerhard M Oremek
Background: This study investigated the usefulness of bone markers Alkaline Phosphatase (AP) and Beta- Crosslaps (ß-CTx) to diagnose, treat and monitor patients with breast carcinoma. AP is a marker of bone formation, while ß-CTx are markers of bone resorption. ß-CTx are expressed as degradation products of collagen type I and can be measured in blood and urine.
Objectives: The aim of this project was to evaluate the significance of bone markers ß-CTx and AP with regard to their usage for early diagnostics of bone metastases and pathological bone metabolism in pre- and postmenopausal patients with known breast cancer.
Materials and Methods: Peripheral blood samples of patients with mammarial diseases (benign and malign) were collected and the bone markers AP and ß-CTx determined. A tot.. Read More»
DOI:
10.4172/2155-9929.1000193
Molecular Biomarkers & Diagnosis received 2054 citations as per Google Scholar report
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