Journal of Blood & Lymph

Gianluca Di Micco

Publications

• Case Report
  Safety of Low Dose of Edoxaban to Treat Acute and Long Term Treatment of a VTE Occurred in a Very Young Adolescent
  Author(s): Pierpaolo Di Micco and Gianluca Di MiccoPierpaolo Di Micco and Gianluca Di Micco
  
  The treatment of VTE with direct oral anticoagulant (DOACs) is a common treatment and therapeutic regimens and timing of treatment are well documented by international guidelines both for initial therapy and for extended therapy. Suggested doses of each drug are established after dose-findings studies and thereafter after phase III clinical trials. Suggested doses of edoxaban to treat VTE are based on 60 mg daily while other available dosages, in particular 30 mg daily are suggested if patients show impaired renal function with moderate kidney failure, low body weight or concomitant use of P-glycoprotein inhibitor drugs. However, there are not studies concerning the optimal treatment with any DOACs and in particular for edoxaban for patients aged less than 18 years, because in dose findings studies and in phase III trials alle selected subjects were major than 18 years old; these info.. Read More»
  DOI: 10.4172/2165-7831.1000191

  Abstract PDF