International Journal of Neurorehabilitation

Gilles van Luijtelaar

Publications

• Research Article
  Effects of Responsive and Scheduled Stimulation in the Subiculum on Seizures and Excitability in the Kainate Induced Temporal Lobe Epilepsy Model
  Author(s): Lili Huang and Gilles van LuijtelaarLili Huang and Gilles van Luijtelaar
  
  Objective: The subiculum, one major output structure in the hippocampus, is considered to participate in seizure generation and modulation in temporal lobe epilepsy (TLE) since stimulation of the subiculum was found to suppress seizures in a seizure model. The current study aimed to investigate whether acute scheduled or responsive stimulation of the subiculum can suppress spontaneous seizures and affect local excitability of the subiculum in a chronic TLE model. Methods: Wistar rats were administrated intraperitoneally with kainic acid (KA) repeatedly to induce status epilepticus (SE). 4 months later the rats were implanted with stimulation electrodes in the subiculum. After one-week baseline recording, they received either responsive or scheduled high frequency stimulation (HFS, 125 Hz) for two days and then were swapped to the other type of .. Read More»
  DOI: 10.4172/2376-0281.1000126

  Abstract PDF