Journal of AIDS & Clinical Research

Giorgio Mancino

Publications

• Research Article
  Impact of Human Leukocyte Antigen Polymorphisms in Human Immunodeficiency Virus Progression in a Paediatric Cohort Infected with a Mono-phyletic Human Immunodeficiency Virus-1 Strain
  Author(s): Carla Montesano, Cesira Tiziana Bonanno, Alba Grifoni, Caterina Di Sano, Paolo Palma, Guido Castelli-Gattinara, Maurizio Mattei, Giorgio Mancino, Alfredo Salerno, Vittorio Colizzi and Massimo AmicosanteCarla Montesano, Cesira Tiziana Bonanno, Alba Grifoni, Caterina Di Sano, Paolo Palma, Guido Castelli-Gattinara, Maurizio Mattei, Giorgio Mancino, Alfredo Salerno, Vittorio Colizzi and Massimo Amicosante
  
  Objective: HLA polymorphisms within the peptide binding pocket have been associated with rapid and slowprogression to AIDS, suggesting that the capability to present efficiently HIV-1 epitopes is crucial for the infection control. To minimize the effects of genetic background due to population coming from different geographic area and viral strain variability in the cohort, an analysis of all the polymorphisms associated with the HLA-A, -B and -DR alleles has been performed in a cohort of children with a monophyletic HIV-1 infection (CRF02_AG) during an outbreak in Libya. Methods: High-resolution HLA-typing has been performed in 58 children infected with a monophyletic strain of HIV-1: 26 Long-Term Non-Progressors (LTNP), 9 Slow-Progressors (SP) and 23 Fast-Progressors (FP). HLA amino acid polymorphism frequency has been compared in the in FP respect to LTNP. Results: .. Read More»
  DOI: 10.4172/2155-6113.1000282

  Abstract PDF