Journal of Tissue Science and Engineering

Gloria Turner

Publications

• Research Article
  Spontaneous Chondrocyte Maturation on 3D-Chitosan Scaffolds
  Author(s): Serafim M Oliveira, Gloria Turner, Simone P Rodrigues, Mário A Barbosa, Mani Alikhani and Cristina C TeixeiraSerafim M Oliveira, Gloria Turner, Simone P Rodrigues, Mário A Barbosa, Mani Alikhani and Cristina C Teixeira
  
  The endochondral ossification mechanism provides promising new insight into potential techniques for repairing bone defects. The methods for replicating endochondral ossification in culture, although diverse, have yet to identify a procedure that reflects natural conditions, while satisfying the practical, experimental needs for efficiency and maneuverability. In this study, we present a novel approach that addresses all of these concerns. Coordinated proliferation and differentiation of chondrocytes in a transient cartilage is required for endochondral bone growth, but the mechanisms and pathways that control these processes are not completely understood. For lack of alternative methods, chondrocyte cultures are commonly pushed to differentiation with growth factors and supplements, like retinoic acid. We have developed a tissue culture model, using .. Read More»
  DOI: 10.4172/2157-7552.1000124

  Abstract PDF