Chemical Sciences Journal

Gopal Krishna Rao

Publications

• Research Article
  Synthesis, Antitubercular and Antibacterial Activities of Some Quinazolinone Analogs Substituted with Benzothiophene
  Author(s): Gopal Krishna Rao and Rajasekaran SubramaniamGopal Krishna Rao and Rajasekaran Subramaniam
  
  A novel series of 3-chloro-N-(4-oxo-2-arylquinazolin-3(4H)-yl)-1-benzothiophene-2-carboxamide analogs derived from 3-amino-2-arylquinazolin-4(3H)-one have been synthesized in good yields and characterized by IR, 1HNMR, mass spectral and elemental analyses. All the compounds were evaluated for their in vitro antibacterial activity against Gram-positive and Gram-negative bacteria and were also screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain by microplate alamar blue method. The compounds 3b and 3h showed good antitubercular and the compound 3a exhibited good antibacterial activity. .. Read More»
  

  Abstract PDF