Journal of AIDS & Clinical Research

Grace A McComsey

Publications

• Research Article
  Changes in Inflammation, Oxidative Stress, Mitochondrial DNA Content after Rosiglitazone in HIV Lipoatrophy
  Author(s): Marisa Tungsiripat, Dalia El-Bejjani, Nesrine Rizk, Bo Hu, Allison C Ross, Ulrich A Walker, Dirk Lebrecht, Ginger Milne, Norma Storer and Grace A McComseyMarisa Tungsiripat, Dalia El-Bejjani, Nesrine Rizk, Bo Hu, Allison C Ross, Ulrich A Walker, Dirk Lebrecht, Ginger Milne, Norma Storer and Grace A McComsey
  
  Objective: We aim to evaluate the mechanisms of rosiglitazone-induced fat recovery in HIV+ patients with lipoatrophy on thymidine Nucleoside Reverse Transcriptase Inhibitors (NRTI) sparing regimens. Method: Measures of limb fat (DXA), oxidative stress (F2 isoprostanes) and inflammation [High-sensitivity C - reactive protein (hsCRP), soluble Tumor Necrosis Factor Receptors (sTNFR)-I, sTNFR-II, and interleukin (IL)-6] were performed. Gluteal fat mitochondrial DNA (mtDNA) and peroxisome proliferator-activated receptor (PPAR)-γ RNA [expressed as PPAR-γ/Glyceraldehyde 6-Phosphate Dehydrogenase (GAPDH) RNA ratio] were measured by quantitative PCR. Result: 71 patients on thymidine NRTI-sparing regimens were randomized to rosiglitazone vs. placebo for 48 weeks. Duration off thymidine NRTIs was similar between groups. From week 0-48, limb fat increased significantly (p=0.02) more i.. Read More»
  DOI: 10.4172/2155-6113.1000174

  Abstract PDF