Neurological Disorders

Grace Ha

Publications

• Review Article
  Reversal of Neuronal Atrophy: Role of Cellular Immunity in Neuroplasticity and Aging
  Author(s): Zhi Huang, Grace Ha and John PetittoZhi Huang, Grace Ha and John Petitto
  
  Emerging evidence indicates that neuroimmunological changes in the brain can modify intrinsic brain processes that are involved in regulating neuroplasticity. Increasing evidence suggests that in some forms of motor neuron injury, many neurons do not die, but reside in an atrophic state for an extended period of time. In mice, facial motor neurons in the brain undergo a protracted period of degeneration or atrophy following resection of their peripheral axons. Reinjuring the proximal nerve stump of the chronically resected facial nerve stimulates a robust reversal of motor neuron atrophy which results in marked increases in both the number and size of injured motor neurons in the facial motor nucleus. In this brief review, we describe research from our lab which indicates that the reversal of atrophy in this injury model is dependent on normal cellular immunity. The role of T cells in.. Read More»
  DOI: 10.4172/2329-6895.1000170

  Abstract PDF