Cancer Science & Therapy

Gregory Lee

Publications

• Review Article
  The Relationships between Toll-like Receptors and RP215-associated Immunoglobulins Expressed by Cancer Cells
  Author(s): Gregory Lee, Cheng-Yuan Huang, Hao Zhang and Yiting TangGregory Lee, Cheng-Yuan Huang, Hao Zhang and Yiting Tang
  
  Relationships between the expressions of immunoglobulins by cancer cells and those of toll-like receptors were investigated through comparative gene regulation studies to understand their roles and mechanisms of action in cancer immunology. RP215 is a monoclonal antibody generated in 1987 and found to recognize the carbohydrate-associated epitope which is detected preferentially in the heavy chains of immunoglobulins expressed by cancer cells, but not in normal immune cells. In this report, RP215 was used to study interactions of cancerous immunoglobulins with toll-like receptors in the innate immunity of cancer cells. From gene regulation studies, with OC-3-VGH ovarian and C-33A cervical cancer cell lines, it was demonstrated that the expressions of cancerous toll-like receptors (TLR-2, -3, -4, -6, -7 and -9) are strongly influenced by the incubation of c.. Read More»
  DOI: 10.4172/1948-5956.1000252

  Abstract PDF