Journal of General Practice

Grosso F

Publications

• Research Article
  Hyponatremia: A Potential Prognostic Biomarker in Malignant Pleural Mesothelioma?
  Author(s): Hudson Z, Grosso F, Charles Comins and Alfredo AddeoHudson Z, Grosso F, Charles Comins and Alfredo Addeo
  
  Objectives Malignant pleural mesothelioma (MPM) remains an incurable and with very poor outcome cancer. The median survival is 12 months with first line therapy; a median survival of 24 months at best when treated with multimodal approach (both neoadjuvant chemotherapy and surgery with or without radiation therapy or postoperative chemotherapy). Identifying a possible prognostic marker would seem imperative. Several studies, all with limited numbers of patients, have tried to find a possible valid and reliable prognostic marker. Univariate and multivariate analyses had been performed, yet the majority of the findings remain invalidated in other MPM populations. It has been recently shown that a reduction in serum sodium could have negative effects on hospitalization length, quality of life and prognosis in cancer patients. Materials and methods We therefore performed a retrospective s.. Read More»
  DOI: 10.4172/2329-9126.1000245

  Abstract PDF