Journal of AIDS & Clinical Research

Guido Norbiato

Publications

• Review Article
  Cross-Talk among Glucocorticoids, Glucocorticoid Receptors and Cytokines Pilots Inflammatory, Endocrine, Immune and Metabolic Responses in HIV Infection
  Author(s): Guido NorbiatoGuido Norbiato
  
  A number of diseases including viral and bacterial infections, inflammatory and auto-immune disorders is associated with glucocorticoids resistance. Tissue resistance to glucocorticoids is observed in untreated HIV infected patients with hypercortisolism. These patients show a complete inability of glucocorticoids to exert their effect, full Addisonian symptoms and an impressive increase in type-1 Th-directed cellular immunity. This clearly suggests a severe receptor resistance to glucocorticoids. Removal of glucocorticoids by adrenal insufficiency or decreased glucocorticoid receptors sensitivity, likely induced by HIV RNA, endotoxin and lipopolysaccarides, significantly enhances morbidity and mortality in such patients. Highly active antiretroviral therapy is an important advance in the treatment of HIV infection since confers survival and acceptable conditions of life, but the supp.. Read More»
  DOI: 10.4172/2155-6113.S5-007

  Abstract PDF