Journal of AIDS & Clinical Research

Guido-Jimenez Miriam

Publications

• Research Article
  P16^ink4a Immunoexpression Profile in HPV-Oral Lesions from HIV-Infected Patients
  Author(s): Rosales-Terrazas Estrella, Ramirez-Amador Velia, Garcia-Carranca Alejandro, Guido-Jimenez Miriam, Irigoyen-Camacho Esther, Ortiz-Sanchez Elizabeth and Anaya-Saavedra GabrielaRosales-Terrazas Estrella, Ramirez-Amador Velia, Garcia-Carranca Alejandro, Guido-Jimenez Miriam, Irigoyen-Camacho Esther, Ortiz-Sanchez Elizabeth and Anaya-Saavedra Gabriela
  
  Background: In HIV-patients, a proportion of benign HPV-associated oral lesions (HPV-OLs) contain high risk- HPV (HR-HPV) sequences. Recent studies demonstrated a p16INK4a overexpression in HPV-induced cancer and dysplastic lesions through pRB degradation by the E7-HPV oncoprotein; so, it has been considered a surrogate marker of HR-HPV oncogenic activity. Objective: To establish the p16INK4a expression in HPV-OL from HIV-infected patients. Materials and method: A cross-sectional study was conducted in three HIV/AIDS referral centers in Mexico City. We performed histopathological diagnosis, HPV-DNA amplification, direct sequencing, and p16INK4a immunohistochemical staining in HPV-OLs. The U-Mann-Whitney, X2, and Fisher’s exact tests were used to determine the association between variables. Result: In a total of 849 adult HIV-individuals exami.. Read More»
  DOI: 10.4172/2155-6113.1000411

  Abstract PDF