Chemical Sciences Journal

Gyorgy Keglevich

Publications

• Research Article
  Synthesis of Phosphinic Acid Derivatives; Traditional Versus up-to-Date Synthetic Procedures
  Author(s): Gyorgy Keglevich, Nora Zsuzsa Kiss and Zoltan MucsiGyorgy Keglevich, Nora Zsuzsa Kiss and Zoltan Mucsi
  
  Synthetic methods for the preparation of phosphinic derivatives (esters and amides) are summarized. The basic method is, when phosphinic chlorides are reacted with alcohols or amines. These reactions take place under mild conditions, but utilize expensive chlorides, need a solvent, and a base has to be added to remove the HCl formed. On conventional heating, the phosphinic acids resist undergoing derivatizations by nucleophiles. However, on microwave (MW) irradiation, the phosphinic acids could be esterified by alcohols. The direct esterification does not require an extra solvent, it is atomic efficient, but needs a relatively higher temperature. The similar amidations were reluctant. Phosphinic acids may also be esterified by alkylation that may be promoted by combined phase transfer catalysis and MW irradiation. It is also possible .. Read More»
  

  Abstract PDF