Nuclear Medicine & Radiation Therapy

Hala A Zaghloul

Publications

• Research Article
  Intensity Modulated Radiotherapy Using Multiple in Fields Compared to Wedged Fields in Breast Irradiation: Clinical Impact on Early Skin Reaction and Organs at Risk Doses
  Author(s): Hala A Zaghloul, Yasser A Rashed, Arif A Shaukat, Yousry A Rostom and Samy E BadawyHala A Zaghloul, Yasser A Rashed, Arif A Shaukat, Yousry A Rostom and Samy E Badawy
  
  Objective: To measure the impact of multiple fields in filed (MFIF) technique on dose homogeneity, doses to organs at risk (OARs) and acute skin toxicity in comparison to physical wedged (PW) tangential technique. Methods: The study population consisted of 75 patients who had breast-conserving surgery and whole-breast radiation using MFIF. These patients were matched one-to-one to a control group of 75 patients treated with PW tangents, following ethical board approval and signing informed consents. Acute skin reaction was graded by CTCAE 3.0 scoring and multiple regression analysis of covariates was performed. Results: CTCAE grade2 acute skin reaction occurred in 61.3% PW vs. 32% MFIF while grade 3 was encountered in 24% PW vs. 10.7% MFIF patients (P<0.01). Multiple regression analysis confirmed the excessive skin reaction to the related radiation therapy technique (P=0.0002) and .. Read More»
  DOI: 10.4172/2155-9619.1000176

  Abstract PDF