West Indies
Research Article
The Effect of Different Doses of Oral Salinomycin on Oxidative Stress Biomarkers in Sheep
Author(s): Ali Hajimohammadi, Hameed Rajaian, Somayeh Jafari and Saeed NazifiAli Hajimohammadi, Hameed Rajaian, Somayeh Jafari and Saeed Nazifi
Salinomycin is a substance which is able to transport particular substance with antimicrobial properties. It is a dietary additive used as a growth promoter for ruminants and as a Veterinary Medicine in chickens. However, over dosage or misuse situations can lead to a series of toxic syndromes. The purpose of this study is to propose the alteration of oxidative stress markers during experimental toxicosis with salinomycin in sheep. Twenty Iranian mixed breed adult female fat-tailed sheep (BW: 36 ± 3.5 kg) were used in this study. Sheep were randomly divided into five equal groups. Group I (control) received 20 ml normal saline. Groups II, III, IV and V were orally administered 1 mg/kg (twice a day for two days), 2, 3 and 4 mg/kg (once a day for two days) salinomycin, respectively. Following drug administration, blood samples were collected at different time intervals (2, 5, 8, 14.. Read More»
DOI:
10.4172/2157-7579.1000243
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