Molecular Biomarkers & Diagnosis

Hamid Reza Sadeghnia

Publications

• Review Article
  The Role of Histone Deacetylase (HDAC) as a Biomarker in Cancer
  Author(s): Malihe Moradzadeh, Alijan Tabarraei and Hamid Reza SadeghniaMalihe Moradzadeh, Alijan Tabarraei and Hamid Reza Sadeghnia
  
  Histone acetylases [HAT] and histone deacetylases [HDACs] are responsible for the addition and removal of acetyl-groups to or from specific lysine residues located within histone tails and a number of non-histone proteins. HDACs, as one of the epigenetic mechanisms, play a central role in the regulation of cellular properties that related to development and progression of cancer. Recently, researches began to focus on the expression patterns of HDAC isoforms as a biomarker in cancer. It could be used to find new agents that are very effective in inducing apoptosis, differentiation, and/or cell growth arrest in neoplasia. Approximately, all of studies showed HDAC expression level differ in human tumors. For example, in most tumor entities class I HDAC expression was higher in late stage, high-grade tumors with strong proliferative activity and Class II HDACs down regulated in human tum.. Read More»
  DOI: 10.4172/2155-9929.1000240

  Abstract PDF