Molecular Biomarkers & Diagnosis

Han Zhang

Publications

• Research Article
  Analysis on the Potential Clinical Bio-marks for Decabromodiphenyl Ether Exposure
  Author(s): Hongmei Wang, Beidou Xi, Hongyan Wang, Han Zhang, Congli Ma, Yuguo Jiao and Yuejiao ZhangHongmei Wang, Beidou Xi, Hongyan Wang, Han Zhang, Congli Ma, Yuguo Jiao and Yuejiao Zhang
  
  Decabromodiphenyl ether (BDE 209) was one of the flame retardants in a variety of commercial and household products. The toxicity of BDE 209 was thought to be associated with neurotoxicity, changes in fetal development, and endocrine disruption etc. Although different toxicology effects of BDE 209 exposure had been reported, the information of BDE 209 on Jurkat cells was still insufficient, and the molecular bio-marks were still unknown. In this research, the gene expression profiling was analyzed. Changes of gene expression induced by BDE 209 could be classified into neurotoxicity, apoptosis and reproductive toxicity. Quantifying microRNA expression levels was verified by real-time PCR. The expression levels of Brain-Derived Neurotrophic Factor (BDNF), Regulating synaptic membrane exocytosis 3 (RIMS3) and dihydropyrimidinase-like 3 (DPYSL3), which were associated with the neurotoxici.. Read More»
  DOI: 10.4172/2155-9929.1000137

  Abstract PDF