Medicinal Chemistry

Hao Cai

Publications

• Research Article
  Synthesis and Biological Evaluation of Novel Furozan-Based Nitric Oxide-Releasing Derivatives of 23-Hydroxy Betulinic Acid and 3-oxo-23-hydroxybetulinic acid as Potential Anti-Tumor Agents
  Author(s): Jie Liu, Fei Sun, Hengyuan Zhang, Hao Cai, Hequan Yao, Weijia Xie, Jieyun Jiang, Xiaoming Wu and Jinyi XuJie Liu, Fei Sun, Hengyuan Zhang, Hao Cai, Hequan Yao, Weijia Xie, Jieyun Jiang, Xiaoming Wu and Jinyi Xu
  
  To search for novel nitric oxide (NO)-releasing anti-tumor agents, two series of furoxan-based NO-releasing derivatives of 23-Hydroxybetulinic acid and 3-oxo-23-hydroxybetulinic acid were designed and synthesized. The nitrate/nitrite levels in the cell lysates were assayed and the results showed that these derivatives could produce high levels of NO in vitro. Then the antiproliferative activity of these hybrids against four human cancer cell lines was further determined, among which, compound 20a was the most promising derivative with an IC50 under 10 μM on all tested cell lines. The preliminary structure-activity relationships were concluded based on present experimental data. .. Read More»
  DOI: 10.4172/2161-0444.1000239

  Abstract PDF