Molecular and Genetic Medicine

Hayashi C

Publications

• Research Article
  Comparative Analysis of Intronic Noncoding RNA Genes among Organisms
  Author(s): Kondo Y, Hayashi C and Miyazaki SKondo Y, Hayashi C and Miyazaki S
  
  Development of sequencing techniques allowed us to determine genomic sequences in many organisms. Such a determined genome consists of not only protein-coding genes but also noncoding RNA (ncRNA) genes. We should analyze evolutional histories of such genes to estimate evolutional directions in future. Meanwhile, recent studies showed that some ncRNA genes are located in intragenic regions in protein-coding genes, which are called host genes. We considered that such information can help us to discuss gene evolutions. In this study, we constructed a database to analyze evolutions of protein-coding and noncoding genes based on gene locations in genomic sequences. We found that 547 out of 2,691 human host genes are orthologous to 546 out of 1,633 mouse host genes. Such orthologous host genes are involved in similar biological functions but some non-orthologous host genes have different fu.. Read More»
  

  Abstract PDF