Journal of Cytology & Histology

Heba M. Eltokhey

Publications

• Research Article
  Tibolone Improves the Degenerative Changes of Tongue Mucosa in Ovariectomized Female Rats
  Author(s): Heba M. Eltokhey, Dalia H. Zahran and Amel M. EzzatHeba M. Eltokhey, Dalia H. Zahran and Amel M. Ezzat
  
  The aim of this study was to investigate the possible effect of sex steroid deficiency on the mucosa of rat tongue as well as the influence of Tibolone. Methods: The tongue mucosa of ovariectomized rats (OVX) was compared to sham-operated rats by histology, immunohistochemistry and electron microscopy. The same evaluation was also performed after hormone replacement therapy. Results: The OVX animals demonstrated significant degenerative changes of tongue mucosa such as reduced thickness of epithelium with an irregular, significantly thinner keratinized surface. Partial disappearance of lingual papilla with irregular epithelial ridges were also noted. At ultrastructural level there were wide intercellular spaces, swollen and/or degenerated mitochondria, irregular dense nuclei, dilated perinuclear cisternae, cytopl.. Read More»
  DOI: 10.4172/2157-7099.1000130

  Abstract PDF