International Peace Maternity and Child Health Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine,
Shanghai 200030
IR Iran
Research Article
Androgen Receptor Alternative Splicing and Human Infertility
Author(s): Chen-Ming Xu, Shu-Yuan Li, Jun-Yu Zhang, Ye Liu, Jie-Xue Pan, Cheng Li and He-Feng HuangChen-Ming Xu, Shu-Yuan Li, Jun-Yu Zhang, Ye Liu, Jie-Xue Pan, Cheng Li and He-Feng Huang
About 95% of multi-exonic genes express more than one mRNA and downstream proteins by alternative splicing (AS) through the inclusion or exclusion of specific exons. Although AS provides a significant advantage in human evolution by increasing proteomic diversity, deregulation of AS can result in various pathologic conditions. The androgen receptor (AR), encoded by AR gene, is a steroid receptor transcription factor which mediates the cellular functions of androgen. The AR-mediated androgen actions play important and dual roles in the human reproduction development and function. Dysregulation of AR will result in human infertility. Multiple AR alternative splicing variants have been identified in different pathologies conditions, including androgen insensitivity syndrome, which will cause male infertility. More recently, our group has identified two AR splice variants expressed in gra.. Read More»
DOI:
10.4172/2168-9547.1000132
Molecular Biology: Open Access received 607 citations as per Google Scholar report
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