Journal of Nephrology & Therapeutics

Heidi Moretti

Publications

• Research Article
  Biotin Deficiency as a Target for Treating Restless Legs Syndrome in Chronic Dialysis Patients
  Author(s): Heidi Moretti, Nell Matthews, John David Anthony Lakatua, Tammy Keeling-Hathaway and Donald M MockHeidi Moretti, Nell Matthews, John David Anthony Lakatua, Tammy Keeling-Hathaway and Donald M Mock
  
  Restless Legs Syndrome is a neuropathic disorder seen in end stage renal disease. Since biotin is dialyzable, we examined the relationship between biotin status and Restless Legs Syndrome in end stage renal disease (Study 1) and determined the effect of biotin supplementation on Restless Legs Syndrome symptoms (Study 2). Comparison of prevalence of biotin deficiency in those with and without Restless Legs Syndrome (Study 1) and randomized assignment, double-blinded, placebo-controlled study of biotin supplementation (Study 2) were in a medical center’s outpatient dialysis unit. In Study 1, patients received chronic dialysis and routine biotin supplementation at ≈300 μg daily (10 times the recommended dietary allowance). In the intervention Study 2, biotin was supplemented at 10,000 μg daily for 8 weeks; the placebo group received ≈300 μg of biotin daily. Out.. Read More»
  

  Abstract PDF