Molecular Biomarkers & Diagnosis

Hem D Shukla

Publications

• Research Article
  Proteomic Analysis of Oxidatively Stressed Pancreatic Adenocarcinoma BxPC-3 Cells: Identification of Potential Biomarkers and Therapeutic Targets
  Author(s): Hem D Shukla and Paul VaietiecunasHem D Shukla and Paul Vaietiecunas
  
  Pancreatic cancer is one of the most aggressive human malignancies and ninth leading cause of cancer death in the world. Most patients diagnosed with pancreatic cancer die within 6 months, and only 4% survive 5 years after diagnosis. Approximately one-fifth of patients with presumably ‘curable’ Pancreatic Ductal Adenocarcinoma (PDA) experience impending relapse and death, making surgical removal almost futile. Early diagnostic, prognostic and predictive biomarkers and better therapeutic options which could help personalize treatment regimens are desperately needed to improve the survival rate of pancreatic cancer patients. By employing BxPC-3 cell line model, high throughput comparative, quantitative and system proteomic analysis, we have been able to identify annexin-a4, annexin-a5 annexin a-11, caveolin-1, EGFR, H-RAS, Integrin-α6β4 proteins which were signific.. Read More»
  DOI: 10.4172/2155-9929.1000149

  Abstract PDF