Molecular Biomarkers & Diagnosis

Heping Xiao

Publications

• Research Article
  Pharmacokinetic Study of Cycloserine in Rat Lung and Blood Tissues
  Author(s): Liping Yan, An Xie, Zhuo Wang, Wenjing Zhang, Yi Huang and Heping XiaoLiping Yan, An Xie, Zhuo Wang, Wenjing Zhang, Yi Huang and Heping Xiao
  
  Objective: To investigate the pharmacokinetics of cycloserine in healthy rat blood and lung tissues. Method: Healthy rat blood and lung tissues were sampled in vivo by microdialysis sampling technique simultaneously. The concentrations of cycloserine in both blood and lung tissues were measured by high performance liquid chromatography mass spectrometry. All date were analyzed by WinNonlin software Results: The maximum concentration of free cycloserine in blood and lung tissue was (10.61 ± 2.42) mg/L and (1.53 ± 1.71) mg/L at 1 h and then both continued to decline. After administration the concentrations of free cycloserine in the blood has been higher than the concentrations in lung tissues. The area under the concentration curve (AUC) of free cycloserine was (33.53 ± 6.51) h.mg-1.L-1 in blood.. Read More»
  DOI: 10.4172/2155-9929.1000230

  Abstract PDF