Cardiovascular Diseases & Diagnosis

Hideki Katoh

Publications

• Research Article
  Intracellular Renin Protects Cardiomyocytes from Ischemic Injury in Diabetic Heart
  Author(s): Daishi Nonaka, Hideki Katoh, Azumi Kumazawa, Terumori Satoh, Masao Saotome, Tsuyoshi Urushida, Hiroshi Satoh and Hideharu HayashiDaishi Nonaka, Hideki Katoh, Azumi Kumazawa, Terumori Satoh, Masao Saotome, Tsuyoshi Urushida, Hiroshi Satoh and Hideharu Hayashi
  
  Background: Local Renin-Angiotensin-Aldosterone system (RAS) is important in cardiac pathophysiology. We investigated the expression and distribution of intracellular renin after ischemia, and the effects of renin on mitochondrial function in diabetic heart. Methods: In Goto-Kakizaki (DM) and Wistar (non-DM) rats, Langendorff-perfused hearts were subjected to ischemia by coronary artery ligation for 90 min. Infarct Size (IS) and expression of RAS components were examined. Mitochondrial membrane potential (ΔΨm), uncoupling protein-2 (UCP2), NAD/NADH ratio, and ATP were measured in renin-treated myocytes or isolated mitochondria. Results: After ischemia, LV function (LVDP; 76 ± 4 vs. 52 ± 4 mmHg, LVEDP; 18 ± 2 vs. 29 ± 4 mmHg, p<0.05, DM; n=9, non-DM; n=9, respectively) was pr.. Read More»
  DOI: 10.4172/2329-9517.1000214

  Abstract PDF