Cancer Science & Therapy

Hideki Tanzawa

Publications

• Research Article
  Neoadjuvant Chemotherapy with S-1 for Patients with Oral Squamous Cell Carcinoma
  Author(s): Hidetaka Yokoe, Atsushi Kasamatsu, Katsunori Ogawara, Takashi Ishigami, Yasunori Sato, Masashi Shiiba, Hideki Tanzawa and Katsuhiro UzawaHidetaka Yokoe, Atsushi Kasamatsu, Katsunori Ogawara, Takashi Ishigami, Yasunori Sato, Masashi Shiiba, Hideki Tanzawa and Katsuhiro Uzawa
  
  S-1, an oral anticancer drug, is comprised of tegafur (a prodrug of 5-fluorouracil) and two biochemical modulators that have effect-enhancing and adverse reaction-reducing activities. Neoadjuvant chemotherapy (NAC) using S-1 has not been reported. Between April 2003 and March 2008, 103 patients with previously untreated oral squamous cell carcinoma (OSCC) received some courses of S-1 NAC (S-1 80 mg/m2/day as the NAC until 1 week preoperatively). Tumor size and histopathologic effect were evaluated before and after treatment. Among 103 cases, 10 cases had complete responses and 53 cases had partial responses (overall response rate [RR], 61.2%). Twenty-two (21.4%) patients had adverse events. Most patients had mild toxicities in the bone marrow and digestive tract (grade 1, 19 cases). Only three patients (2.9%) had grade 2 neutropenia or grade 4 thrombocytopenia. We examined the relatio.. Read More»
  DOI: 10.4172/1948-5956.1000038

  Abstract PDF