Molecular Biomarkers & Diagnosis

Hillary Kimbrell

Publications

• Research Article
  Analytical Validation of a Cell Cycle Progression Signature Used as a Prognostic Marker in Prostate Cancer
  Author(s): M. Bryan Warf, Julia E. Reid, Krystal L. Brown, Hillary Kimbrell, Kathryn A. Kolquist, Steven Stone and Benjamin RoaM. Bryan Warf, Julia E. Reid, Krystal L. Brown, Hillary Kimbrell, Kathryn A. Kolquist, Steven Stone and Benjamin Roa
  
  Background: Prostate cancer is the most common cancer in men in the developed world. Appropriate clinical care requires accurate prognostic information to determine whether definitive treatment or conservative management is most appropriate for a given patient. We previously demonstrated that a gene expression signature, which measures the RNA expression of 31 cell cycle progression (CCP) genes and generates a CCP score, is a robust predictor of patient outcome in cohorts of conservatively managed patients diagnosed by needle biopsy or transurethral resection of the prostate. Methods: These current studies represent the analytical validation of this gene signature, for the testing of either formalin-fixed paraffin-embedded (FFPE) prostate resection tissue (radical prostatectomy, RP) or FFPE prostate needle biopsy samples. R.. Read More»
  DOI: 10.4172/2155-9929.1000239

  Abstract PDF