Journal of Hypertension: Open Access

Hiroyuki Seki

Publications

• Research Article
  The Progression of Serum Prorenin Concentration during Pregnancy
  Author(s): Yukiko Mikami, Tatsuya Narita, Yasushi Takai, Kazunori Baba, Hiroyuki Seki and Kikumi MatsuokaYukiko Mikami, Tatsuya Narita, Yasushi Takai, Kazunori Baba, Hiroyuki Seki and Kikumi Matsuoka
  
  Objective: An association between the renin-angiotensin system and the pathogenesis of pregnancy-induced hypertension has been reported. The prorenin receptor was discovered in 2002, and Wanatabe et al. reported that women with plasma soluble prorenin receptor concentrations above the 75th percentile at delivery had a significantly increased risk of preeclampsia. We evaluated serum prorenin concentrations during pregnancy, and we assessed the incidence of pregnancy-induced hypertension. Methods: We measured serum prorenin concentrations in 430 pregnant women (565 samples). Regression analysis was performed to determine the associations between the serum prorenin level and maternal/neonatal complications. Results: The serum prorenin concentration and gestational age had a positive correlation in non-pregnancyinduced.. Read More»
  DOI: 10.4172/2167-1095.1000166

  Abstract PDF