Journal of AIDS & Clinical Research

Hoai Ton

Publications

• Review Article
  Astrocyte Dysfunctions and HIV-1 Neurotoxicity
  Author(s): Hoai Ton and Huangui XiongHoai Ton and Huangui Xiong
  
  Astrocytes play an important role in maintaining an optically suited milieu for neuronal functionality, and are involved in the progression and outcome of many neuropathological conditions. It becomes increasingly evident that astrocytes are significant contributors to HIV-1 associated neurological disorders by modulating the microenvironment in the central nervous system and releasing proinflammatory cytokines. Recent studies have revealed direct metabolic interactions between neurons and astrocytes observed particularly in HIV-1-associated neurological disorders by which astrocytic dysfunctions disregulate extracellular K+ homeostasis, intracellular calcium concentration, glutamate clearance, and blood brain barrier integrity and permeability. Such dysfunctions are amplified via gap junctions, directly or indirectly impacting surrounding neurons and significantly contributing to the.. Read More»
  DOI: 10.4172/2155-6113.1000255

  Abstract PDF