Medicinal Chemistry

Hong LIU

Publications

• Research Article
  Synthesis and Evaluation of Anti-HIV-1 Activities of Novel 7-Hydroxy-1,3- dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-4-carboxylate Derivatives
  Author(s): Guan-Nan LIU, Rong-Hua LUO, Xing-Jie ZHANG, Yu ZHOU, Jian LI, Yong-Tang ZHENG and Hong LIUGuan-Nan LIU, Rong-Hua LUO, Xing-Jie ZHANG, Yu ZHOU, Jian LI, Yong-Tang ZHENG and Hong LIU
  
  Aim: To design and synthesize a series of novel 7-hydroxy-1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-4- carboxylate derivatives and evaluate their anti-HIV-1 activities. Methods: Holding the same triad of metal-chelating heteroatoms for the catalytic site of IN and introducing a new hydroxyl group into the adjacent position of the amide to form another three-heteroatoms group for metal chelation, a series of novel 7-hydroxy-1,3-dioxo-2,3-dihydro-1Hpyrrolo[ 3,4-c]pyridine-4-carboxylate derivatives were designed and synthesized through multi-step chemical reactions. All the synthesized compounds were evaluated for their inhibitory activities against HIV-1 replication. Results: Thirtyfive new compounds (5–13) have been designed, synthesized and bioassayed. Their structural features were determined by 1H-NMR sp.. Read More»
  DOI: 10.4172/2161-0444.1000196

  Abstract PDF