Journal of Cytology & Histology

Hongyu Li

Publications

• Research Article
  Increased Expression of PITX2, LEF-1,beta-Catenin in Epithelial Ovarian Cancer
  Author(s): Huanhuan Guo, Hai Zhu, Shujun Zhao, Min Zhang, Xingshuo Liu, Huihui Han, Meng Cao, Li Dong and Hongyu LiHuanhuan Guo, Hai Zhu, Shujun Zhao, Min Zhang, Xingshuo Liu, Huihui Han, Meng Cao, Li Dong and Hongyu Li
  
  Objective: Pituitary homeobox-2 (PITX2), a member of the bicoid/paired-like homeobox gene family, plays an important role in determining left-right asymmetry in vertebrates and development of multiple organs by serving as a downstream effector of Nodal, TGFβ, and Wnt signaling pathway. PITX2, lymphoid enhancer factor (LEF-1) and beta-catenin are required for the inductive formation of several epithelial-derived organs, including teeth, which remains unclear interaction Wnt signal pathway in the development of ovarian epithelial tumors. Research PITX2, LEF-1 and beta-catenin direct interactions may provide new mechanisms for epithelial ovarian cancer. Materials and methods: 1. Using immunohistochemical (IHC), real-time quantitative RT-PCR (Q-PCR), Western blot to analyse the expression of PITX2, LEF-1, β-catenin in ovarian cancer tiss.. Read More»
  DOI: 10.4172/2157-7099.1000333

  Abstract PDF