Molecular Biomarkers & Diagnosis

Hongzhi Zou

Publications

• Research Article
  Selection of Sensitive Methylation Markers for the Detection of Non-small Cell Lung Cancer
  Author(s): Xia Zhao, Jin Jen, Tobias Peikert, Eric Edell, Shulan Tian, Ping Yang, Yajue Huang and Hongzhi ZouXia Zhao, Jin Jen, Tobias Peikert, Eric Edell, Shulan Tian, Ping Yang, Yajue Huang and Hongzhi Zou
  
  Introduction: While early-stage lung cancer is curable by surgical resection, most patients are diagnosed with advanced- stage disease. Annual low-dose computed tomography screening decreases lung cancer mortality, however effective biomarkers to address the high false positive rate and to better define high risk individuals are lacking. This study was designed to identify potential DNA methylation markers for the detection of non-small cell lung cancer, the most common type of lung cancer. Methods: 152 candidate methylation genes were first investigated in lung cancer cell lines and a pilot set of lung tissues. Five promising methylated genes, DMRTA, HOXA9, ZIC4, HOXA7, and SIX3, were selected and further validated in 150 non-small cell lung cancers and 142 tumor-free surrounding lung tissues using the quantitative methylation-specific PCR... Read More»
  DOI: 10.4172/2155-9929.1000250

  Abstract PDF