Cancer Science & Therapy

Hozumi Tsuchiya

Publications

• Research Article
  Association of Butyric Acid Produced by Periodontopathic Bacteria with Progression of Oral Cancer
  Author(s): Yuji Miyazaki, Kentaro Kikuchi, Patricia González-Alva, Harumi Inoue, Yoshihiro Noguchi, Hozumi Tsuchiya, Joichiro Hayashi, Kitetsu Shin, Kuniyasu Ochiai and Kaoru KusamaYuji Miyazaki, Kentaro Kikuchi, Patricia González-Alva, Harumi Inoue, Yoshihiro Noguchi, Hozumi Tsuchiya, Joichiro Hayashi, Kitetsu Shin, Kuniyasu Ochiai and Kaoru Kusama
  
  Objective: The association between periodontal disease and the risk of various human cancers including oral squamous cell carcinoma (OSCC) has been suggested. Butyric acid (BA), an extracellular metabolite from periodontopathic bacteria, plays an important role in the progression of periodontal disease. Recent studies have shown that podoplanin, a transmembrane glycoprotein, is expressed in various normal as well as neoplastic tissues. In this study, the effects of BA/sodium butyrate (NaB) on podoplanin expression, cell migration and epithelial-mesenchymal transition in OSCC cell lines were examined. Methods: Ca9-22, HSC-2, -3 and -4 cells were incubated with NaB, and then subjected to real-time RT-PCR, western blotting and scratch assay. Results: NaB increased the expression of podoplanin in HSC-2 and -3 cells and vimentin in Ca9-22 cells. Cell migration was promoted at a.. Read More»
  

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