Medicinal Chemistry

Hristina Nocheva

Publications

• Research Article
  Effects of Enantiopure (S)-a-Trifluoromethyl Proline Containing MIF-1`s Analogue on Stress-induced Analgesia
  Author(s): Adriana Bocheva, Hristina Nocheva, Ibtissem Jlalia, Nathalie Lensen, Grégory Chaume and Thierry BrigaudAdriana Bocheva, Hristina Nocheva, Ibtissem Jlalia, Nathalie Lensen, Grégory Chaume and Thierry Brigaud
  
  The present study was undertaken to investigate the effects of novel CF3-(MIF-1) analogue on stress-induced analgesia after restraint and cold stress in rats. The analgesic effect of CF3-(MIF-1) has been evaluated by paw pressure (PP) and hot plate (HP), and compared to the native tripeptide MIF-1. Our hypothesis was that incorporation of the trifluoromethyl group (CF3) in the novel MIF-1 analogue molecule would increase its antagonizing effect in both tests and after both kinds of stress compared to the native tripeptide MIF-1. The results obtained showed that both the non-fluorinated and the fluorinated peptides significantly decreased SIA in PP and HP tests during the whole investigated period and CF3-(MIF-1) had a stronger anti-opioid effect compared to MIF-1. .. Read More»
  DOI: 10.4172/2161-0444.1000140

  Abstract PDF