Nuclear Medicine & Radiation Therapy

Hsiu-Huei Peng

Publications

• Case Report
  Seprafilm Mediated Immune Response Mimic Danger Signal: A Pilot Study in Ovarian Cancer Cases
  Author(s): Tzu-Hsuan Chin, Hsiu-Huei Peng and Cheng-Tao LinTzu-Hsuan Chin, Hsiu-Huei Peng and Cheng-Tao Lin
  
  Danger signal was first proposed in 1994. In response to danger signal, dendritic cells, as the director of the T-cell immune system, would be matured and further enhance T-cell response. Hyaluronan had been reported as one of endogenous danger signals. Because of Seprafilm (most used for preventing post-operation adhesion) is also an hyaluronate-based agent, so we choose Seprafilm as our “candidate” of emerging danger signal to increasing T-cell response. We perform a pilot study in 10 ovarian cancer patients to compare the immune risk profiles between cases using Seprafilm (5 cases) and not using Seprafilm (5 cases). We found that there is no statistical difference on the immune risk profiles between two groups. However, a trend of increased CD4 in Seprafilm group was noted, indicating that Seprafilm might be an optional agent mimic dang.. Read More»
  DOI: 10.4172/2155-9619.1000305

  Abstract PDF