Medicinal Chemistry

Hua Jin

Publications

• Research Article
  Mediation of the Anticancer Effects of Resveratrol via the Upregulation of Tristetraprolin in Gastric Cancer Cell
  Author(s): Won-Tae Kim, Hua Jin, Se-Ra Lee, Sung Zoo Kim, Sun-Hee Leem and Soo Mi KimWon-Tae Kim, Hua Jin, Se-Ra Lee, Sung Zoo Kim, Sun-Hee Leem and Soo Mi Kim
  
  Tristetraprolin (TTP) is an mRNA-binding protein that can induce mRNA degradation. It controls cell growth and factors related to tumor development by binding AU-rich elements located in the 3' untranslated region (UTR) of mRNA, leading to rapid mRNA decay. Resveratrol, which is a natural flavonoid polyphenolic compound, has been shown to exert biological activities on various human cancers. However, there are no studies assessing its effects with TTP regulation on human gastric cancer. The present novel study demonstrated that the tumor suppressing effects of resveratrol were mediated via the induction of TTP expression in gastric cancer. We found that resveratrol induced TTP mRNA and protein expression in the gastric cancer cell lines SNU484 and SNU638. Treatment with resveratrol enhanced the decaying activity of TTP on luciferase mRNA containing cIAP2, LATS2, Lin28, an.. Read More»
  DOI: 10.4172/2161-0444.1000494

  Abstract PDF