Cancer Science & Therapy

Hugo Deneo-Pellegrini

Publications

• Research Article
  Alcohol Drinking, Non-alcoholic Beverages and Risk of Advanced Prostate Cancer among Uruguayan Men
  Author(s): Eduardo De Stefani, Hugo Deneo-Pellegrini, Alvaro L Ronco, Paolo Boffetta and Giselle AcostaEduardo De Stefani, Hugo Deneo-Pellegrini, Alvaro L Ronco, Paolo Boffetta and Giselle Acosta
  
  Background: Loss of the membrane endopeptidase CD10 plays an important role in the development of neuropeptide-mediated androgen-independent prostate cancer cell growth. The aim of this study was to investigate the potential prognostic value of the CD10/neuropeptide axis with regard to prostate-specific antigen (PSA) failure after radical prostatectomy (RP) in early prostate cancer (PC) patients. Methods: Tumor samples from 70 early PC patients who underwent RP were immunohistochemically evaluated for expression of CD10 and endothelin-1 (ET-1). The examined parameters were prospectively correlated with time to PSA failure and combined with Gleason grade and pathological TNM stage. Results: Membranous and apical cytoplasmic expression of CD10 was directly correlated with time to PSA fail.. Read More»
  DOI: 10.4172/1948-5956.S1-006

  Abstract PDF