Medicinal Chemistry

Hui-Juan Chen

Publications

• Research Article
  Changes of 1-deoxynojirimycin with Hypoglycemic Activity in Silkworm (Bombyx mori L.) During Different Developmental Stages
  Author(s): Hui-Juan Chen, Ying Shi, Jun Liu, Lixia Mu, Yu-Xiao Zou and Sen-Tai LiaoHui-Juan Chen, Ying Shi, Jun Liu, Lixia Mu, Yu-Xiao Zou and Sen-Tai Liao
  
  Silkworms are drawing international scientific attention owing to their significant hypoglycemic activity, attributed to 1-deoxynojirimycin (DNJ), which they obtain from eating mulberry leaves. DNJ content in silkworms varies significantly during its life cycle as a holometabolic insect. The effect of metamorphosis and molting on DNJ accumulation remains unclear, however. More knowledge is needed about DNJ dynamics during the silkworm life cycle given their potential use as a functional food with hypoglycemic effect. This paper aims to elucidate the DNJ dynamics of silkworms over their life cycle. We propose the best physiological stage for silkworm harvesting in consideration of DNJ production. The effect of metamorphosis and molting on DNJ accumulation is also discussed. Samples from key physiological stages of silkworms were collected and the DNJ c.. Read More»
  DOI: 10.4172/2161-0444.1000205

  Abstract PDF