Journal of Computer Science & Systems Biology

Iddya Karunasagar

Publications

• Research Article
  Molecular Docking Studies of Type III Secretion System Effector Sopb Homolog in Vibrio vulnificus
  Author(s): Rama Adiga, Iddya Karunasagar and Indrani KarunasagarRama Adiga, Iddya Karunasagar and Indrani Karunasagar
  
  Pathogenic bacteria use the needle shaped Type III secretion system to inject effector proteins into the host cell. The SopB effector protein of Salmonella mediates invasion by evading the host immune response. Being a phosphoinositide phosphatase, it synthesizes phospholipids at the host cell membrane, after targeting host cell ubiquitin. Ubiquitination of SopB are known to control the biological activity of SopB at the plasma membrane. The identified SopB effector protein of Vibrio vulnificus which is a human pathogen found in the marine environment was homologous to SopB of Salmonella and E.coli. Structural superposition with available structure of SopB of Salmonella yielded a DNA linking domain similar to Salmonella SopB. Ubiquitination sites for SopB homolog in V.vulnificus was predicted by bioinformatics tools which was further supported by molecular.. Read More»
  DOI: 10.4172/jcsb.1000070

  Abstract PDF