Journal of Blood & Lymph

Iffat Adeel

Publications

• Case Report
  Three Cases of Refractory Anemia with Ringed Sideroblasts Who Responded to Chloroquine
  Author(s): Mohammed Salhab, Ali Zaidi, Iffat Adeel, Sana Saeed, Zeba Aziz, Azra Raza and Michael AuerbachMohammed Salhab, Ali Zaidi, Iffat Adeel, Sana Saeed, Zeba Aziz, Azra Raza and Michael Auerbach
  
  We report three cases of myelodysplastic syndrome (MDS), refractory anemia with ringed sideroblasts (RARS), who responded to the anti-malarial chloroquine in combination with recombinant erythropoietin (darbepoetin alfa). All three patients either remained or achieved transfusion independence and increased their hemoglobin level by at least 1 gm/dl. Responses occurred rapidly, becoming clinically noticeable within the first 4-6 weeks from start of therapy. All patients were followed for at least a 6 months period during which they have remained transfusion independent. Chloroquine affects multiple cellular pathways, but the precise mechanism of its action in RARS patients is unclear. .. Read More»
  DOI: 10.4172/2165-7831.1000125

  Abstract PDF