Clinical Lecturer, Centre for Endocrine and Diabetes Sciences, Institute of Molecular & Experimental Medicine, Cardiff University - School of Medicine,
Room 256, main building block C, second floor (C2 Link Corridor), University Hospital of Wales Heath Park, Cardiff, CF 14 4XN
United Kingdom
Review Article
Melasma and Endocrine Disorders
Author(s): Ilaria Muller and Aled ReesIlaria Muller and Aled Rees
Melasma is an acquired and chronic disorder characterized by a localized symmetrical hypermelanosis of the face or, less frequently, involving the neck and forearms. It occurs with a high prevalence during pregnancy, especially during the second half of the gestational period, and in women taking exogenous female hormones. Melasma has also rarely been described in males, especially those affected by primary hypogonadism or taking estrogens for prostatic cancer. Melasma thus appears to be pathologically related to female sex hormones, but this is not consistently reflected in high circulating levels of estrogens or progesterone. This implies that other factors are likely to be relevant, including genetic predisposition, exposure to ultraviolet light, cosmetics and some medications. Melanocortins play a key role in melanogenesis but no cases of melasma have been described in pituitary o.. Read More»
DOI:
10.4172/2376-0427.1000S1001
Journal of Dermatology and Dermatologic Diseases received 4 citations as per Google Scholar report
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