Journal of Hypertension: Open Access

Indu Sharma

Publications

• Research Article
  Implication of Endothelin-2 and Oxidative Stress Biomarkers in Essential Hypertension
  Author(s): Veena Dhawan, Indu Sharma, Nitin Mahajan, Sonal Malik Sangwan and Sanjay JainVeena Dhawan, Indu Sharma, Nitin Mahajan, Sonal Malik Sangwan and Sanjay Jain
  
  Objectives: Essential hypertension (EH) is a multifactorial disease and oxidative stress has been demonstrated to play an important role in its pathophysiology. Among several genes implicated in the pathophysiology of hypertension, endothelin-2 (ET-2), a potent vasoconstrictor, has been incriminated as a candidate gene for essential hypertension. To find out correlation of in vivo biomarkers of oxidative stress [oxidized low density lipoprotein (Ox-LDL), 8-iso- Prostaglandin F2α (8-iso-PGF2α)] and Nitrite (NO2-) are related to endothelin-2 levels and to determine their value as diagnostic markers in essential hypertension. Methods: 100 subjects with essential hypertension and 150 age and sex-matched normotensive controls were enrolled to determine levels of ET-2, Ox-LDL, 8-iso-PGF2α and NO2-. Results:.. Read More»
  DOI: 10.4172/2167-1095.1000170

  Abstract PDF